Working with industry specialists and offering a broad spectrum of in-house expertise, you can trust Nextmune Laboratories UK with your contract research needs.
We lead research projects with large commercial organisations, SMEs and academic groups, including international pet food manufacturers, biotechnology companies and specialised clinical veterinary groups.
Examples of techniques utilised in projects include; protein characterisation, validation of external ELISA kits for sample analysis, immunoassay development, and the immunorecognition of pet food proteins by ELISA.
Research studies have covered a variety of topics, from allergenic cross-reactivity to the use of novel biomarkers for screening of animals and diagnosis of disease. Many have been presented at international conferences and published in peer-reviewed journals.
Examples of techniques utilised in projects include; protein characterisation, validation of external ELISA kits for sample analysis, immunoassay development, and the immunorecognition of pet food proteins by ELISA.
Research studies have covered a variety of topics, from allergenic cross-reactivity to the use of novel biomarkers for screening of animals and diagnosis of disease. Many have been presented at international conferences and published in peer-reviewed journals.
OUR APPROACH
With extensive experience in reproducible research, our work utilises advanced tools and techniques in data science, ensuring the highest standards for quality results you can trust.
Understanding Immunorecognition of Proteins in Pet Food
We can offer insights into the immunorecognition of proteins present in dog food, which can be valuable for pet food development. This involves using sera from dogs with suspected adverse food reactions. We measure IgE binding to specific proteins in pet foods, employing sera from dogs previously identified as sensitized to allergenic extracts (e.g., chicken, white fish, and lamb).
OUR PUBLICATIONS
- Bethlehem S, Bexley J, Mueller RS. Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions. Vet Immunol Immunopathol. 2012 Feb 15;145(3-4):582-9.
- Bexley J, Hogg JE, Hammerberg B, Halliwell RE. Levels of house dust mite-specific serum immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay. Vet Dermatol. 2009 Oct;20(5-6):562-8.
- Bexley J, Kingswell N, Olivry T. Serum IgE cross-reactivity between fish and chicken meats in dogs. Vet Dermatol. 2018 Oct 30.
- Bexley J, Nuttall TJ, Hammerberg B, Fitzgerald JR, Halliwell RE. Serum anti-Staphylococcus pseudintermedius IgE and IgG antibodies in dogs with atopic dermatitis and nonatopic dogs. Vet Dermatol. 2013 Feb;24(1):19-24.e5-6.
- Bexley J, Nuttall TJ, Hammerberg B, Halliwell RE. Co-sensitization and cross-reactivity between related and unrelated food allergens in dogs – a serological study.Vet Dermatol. 2017 Feb;28(1):31-e7.
- Forsyth, J., Halliwell, R.E. & Harrand, R. (2019). Co-reactivity between related and unrelated environmental allergens in equine allergen-specific IgE serology testing in the UK. Vet. Dermatol.; DOI: 10.1111/vde.12786.
- Olivry T, Bexley J, Mougeot I. Extensive protein hydrolyzation is indispensable to prevent IgE-mediated poultry allergen recognition in dogs and cats. BMC Vet Res. 2017 Aug 17;13(1):251.
- Olivry T, Bexley J. Cornstarch is less allergenic than corn flour in dogs and cats previously sensitized to corn. BMC Vet Res. 2018 Jun 27;14(1):207.
- Zimmer A, Bexley J, Halliwell RE, Mueller RS. Food allergen-specific serum IgG and IgE before and after elimination diets in allergic dogs.Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):442-7.
- Olivry T, Pucheu-Haston C, Mayer U, Bergvall K. & Bexley J. Identification of major and minor chicken allergens in dogs. Vet Dermatol. 2022 Jan;33:46-e16
WORK WITH US
If you are considering outsourcing your contract research services please contact our Customer Support team to discuss your project requirements.